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感染者|JCO：這種常用藥或能幫肝炎患者遠離肝癌！( 二 )

研究胺藥組胺常用藥Journalet分析人群感染者風險病毒患者H1抗組


此外 ， 當前肝炎病毒感染者已經有老齡化趨勢 ， 往往合并多種慢性疾病 ， 需要長期服用阿司匹林、他汀類藥物 ， 而這些藥物也可能有一定的防癌作用 。 將來還得靠前瞻性研究 ， 專門分析H1抗組胺藥到底有多大能耐才行 。
參考文獻：
1.Shen Y C, Hsu H C, Lin T M, et al. H1-Antihistamines Reduce the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus, Hepatitis C Virus, or Dual Hepatitis B Virus-Hepatitis C Virus Infection[J]. Journal of Clinical Oncology, 2022.
2.Feng Y M, Feng C W, Lu C L, et al. Cyproheptadine significantly improves the overall and progression-free survival of sorafenib-treated advanced HCC patients[J]. Japanese Journal of Clinical Oncology, 2015, 45(4): 336-342.
3.Hsieh M C, Lee W H, Wu A T H, et al. Cyproheptadine use in hepatocellular carcinoma[J]. American Journal of Cancer Research, 2017, 7(3): 584.
4.Liang Y C, Chang C C, Sheu M T, et al. The antihistamine deptropine induces hepatoma cell death through blocking autophagosome-lysosome fusion[J]. Cancers, 2020, 12(6): 1610.
5.He S, Lin B, Chu V, et al. Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection[J]. Science Translational Medicine, 2015, 7(282): 282ra49.
6.Li H, Xiao Y, Yao J, et al. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1[J]. Cancer Cell, 2022, 40(1): 36-52.E9.
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