感染者|研究:新冠感染明顯增加血栓風險,輕癥病例也不例外

瑞典一項研究稱 , 感染新冠病毒的人在感染后數月內深靜脈血栓形成和肺栓塞的風險明顯增加 , 即使是輕癥病例也不例外 。 研究人員發現 , 感染者在確診新冠30天后 , 肺栓塞風險增加33倍 , 深靜脈血栓形成風險增加5倍 。
感染者|研究:新冠感染明顯增加血栓風險,輕癥病例也不例外
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【感染者|研究:新冠感染明顯增加血栓風險,輕癥病例也不例外】A man is given a coronavirus disease (COVID-19) test at pop-up testing site in New York City, US, April 11, 2022. [Photo/Agencies]
New observational research out of Sweden has tracked more than one million COVID-19 cases for months after their acute illness in order to determine how the disease influences subsequent risk of blood clots. The findings indicate COVID-19 significantly increases a person’s risk of deep vein thrombosis and pulmonary embolism in the months after infection.瑞典一項觀察研究對100多萬新冠病例進行了數月追蹤 , 以確定新冠是如何影響感染者隨后出現血栓的風險的 。 研究結果表明 , 人們在感染新冠后幾個月內深靜脈血栓形成和肺栓塞的風險明顯增加 。
The large study, published in The BMJ, looked at health data from 1,057,174 positive COVID-19 cases. This covers every single positive recorded case in Sweden from the beginning of the pandemic up to May 2021. A control group of four million age- and sex-matched subjects not positive with COVID was generated to quantify the increase in risk for blood clots caused by infection.這項研究樣本龐大 , 對1057174新冠病毒陽性感染者的健康數據進行了分析 , 涵蓋了瑞典從疫情暴發以來到2021年5月的所有陽性感染者 。 研究設置了一個對照組 , 從而量化感染新冠導致的血栓風險增加程度 , 對照組由400萬年齡和性別相仿的受試者組成 , 這些受試者的新冠病毒檢測結果未呈陽性 。 該研究發表在《英國醫學雜志》上 。
In the 30 days after an initial COVID-19 diagnosis the researchers found a 33-fold increase in pulmonary embolism risk, a five-fold increase in deep vein thrombosis (DVT) risk and a two-fold increase in general bleeding events. The heightened risk, compared to the uninfected control group, persisted 60 days for bleeding, 90 days for DVT, and 180 days for pulmonary embolism.研究人員發現 , 感染者在最初確診新冠30天后 , 肺栓塞風險增加33倍 , 深靜脈血栓形成風險增加5倍 , 一般性出血事件風險增加2倍 。 與未感染新冠的對照組相比 , 出血風險升高持續60天 , 深靜脈血栓形成風險升高持續90天 , 肺栓塞風險升高持續180天 。
Factoring in acute disease severity, the researchers found those initially hit hardest with COVID-19 did experience greater long-term risk for blood clotting events. However, the increased risk was not zero in those experiencing mild COVID. Those with only a mild infection still showed a three-fold risk of DVT and a seven-fold risk of pulmonary embolism.研究人員發現 , 重癥感染者血栓形成的風險更大 。 但輕癥感染者血栓形成的風險也有所增加 。 輕癥患者的深靜脈血栓形成風險增加3倍 , 而肺栓塞風險增加7倍 。
While this new study is the most robust to investigate the relationship between blood clots and SARS-CoV-2 infection it is not the first to identify this association. A large UK study last year found similar signs when it compared rates of hematological and vascular events after COVID-19 to rates of those same events after COVID vaccination.該項最新研究是探索血栓形成與新冠病毒感染之間相關度的最有力研究 , 但它并不是第一項發現這種關聯的研究 。 2021年英國的一項大型研究也發現了類似跡象 , 該研究比較了感染新冠后與接種新冠疫苗后的血液血管疾病的發生率 。