Nature Reviews:2022年腸易激綜合征研究三大進展( 三 )


3.Mars,R.A.T.etal.Longitudinalmulti-omicsrevealssubset-specificmechanismsunderlyingirritablebowelsyndrome.Cell183,1137–1140(2020).
4.Mujagic,Z.etal.Integratedfecalmicrobiome–metabolomesignaturesreflectstressandserotoninmetabolisminirritablebowelsyndrome.GutMicrobes14,2063016(2022).
5.McIntosh,K.etal.FODMAPsaltersymptomsandthemetabolomeofpatientswithIBS:arandomisedcontrolledtrial.Gut66,1241–1251(2017).
6.DePalma,G.etal.Histamineproductionbythegutmicrobiotainducesvisceralhyperalgesiathroughhistamine4receptorsignalinginmice.Sci.TranslMed.14,eabj1895(2022).
7.Barbara,G.etal.Mastcell-dependentexcitationofvisceral-nociceptivesensoryneuronsinirritablebowelsyndrome.Gastroenterology132,26–37(2007).
8.Deiteren,A.etal.HistamineH4andH1receptorscontributetopostinflammatoryvisceralhypersensitivity.Gut63,1873–1882(2014).
9.Carbone,F.etal.DietormedicationinprimarycarepatientswithIBS:theDOMINOstudy-arandomisedtrialsupportedbytheBelgianHealthCareKnowledgeCentre(KCETrialsProgramme)andtheRomeFoundationResearchInstitute.Gut71,2226–2232(2022).
10.Howell,C.A.etal.Double-blindedrandomisedplacebocontrolledtrialofenterosgel(polymethylsiloxanepolyhydrate)forthetreatmentofIBSwithdiarrhoea(IBS-D).Gut71,2430–2438(2022).
原文鏈接:
https://www.nature.com/articles/s41575-022-00718-3
作者:MagnusSimrén
編譯:Dayu
審校:617
編輯:豫小魚返回搜狐 , 查看更多
Nature Reviews:2022年腸易激綜合征研究三大進展】責任編輯: