最新臨床結果:間充質干細胞有效減緩SMA疾病進展,顯著延長生存期( 二 )


最新臨床結果:間充質干細胞有效減緩SMA疾病進展,顯著延長生存期
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相信隨著科學研究和臨床試驗的廣泛開展 , 間充質干細胞治療有望成為脊髓性肌萎縮癥的新一代治療方案 , 為更多尚在襁褓就被判處死刑的孩子帶來生命的曙光 。
參考文獻
[1]Mohseni,R.,Hamidieh,A.A.,Shoae-Hassani,A.etal.Anopen-labelphase1clinicaltrialoftheallogeneicsidepopulationadipose-derivedmesenchymalstemcellsinSMAtype1patients.NeurolSci(2021).https://doi.org/10.1007/s10072-021-05291-2
[2]KeinathMC,PriorDE,PriorTW(2021)Spinalmuscularatrophy:mutations,testing,andclinicalrelevance.ApplClinGenet25(14):11–25.https://doi.org/10.2147/TACG.S239603
[3]LiT,MaH,MaH,MaZ,QiangL,YangZ,YangX,ZhouX,DaiK,WangJ(2019)Mussel-inspirednanostructurespotentiatetheimmunomodulatorypropertiesandangiogenesisofmesenchymalstemcells.ACSApplMaterInterfaces11(19):17134–17146.https://doi.org/10.1021/acsami.8b22017
[4]UrrutiaDN,CaviedesP,MardonesR,MinguellJJ,Vega-LetterAM,JofreCM(2019)Comparativestudyoftheneuraldifferentiationcapacityofmesenchymalstromalcellsfromdifferenttissuesources:anapproachfortheiruseinneuralregenerationtherapies.PLoSOne14(3):e0213032.https://doi.org/10.1371/journal.pone.0213032
[5]JinJ,ShiY,GongJ,ZhaoL,LiY,HeQ,HuangH(2019)Exosomesecretedfromadipose-derivedstemcellsattenuatesdiabeticnephropathybypromotingautophagyfluxandinhibitingapoptosisinpodocyte.StemCellResTher10(1):95.https://doi.org/10.1186/s13287-019-1177-1
[6]FengM,LiuC,XiaY,etal.RestorationofSMNexpressioninmesenchymalstemcellsderivedfromgene-targetedpatient-specificiPSCs.JMolHistol.2018;49(1):27-37.https://doi.org/10.1007/s10735-017-9744-1